The transcription factor MZF1 differentially regulates murine <i>Mtor</i> promoter variants linked to tumor susceptibility.

Zhang, Shuling; Shi, Wei; Ramsay, Edward S; Bliskovsky, Valery; Eiden, Adrian Max; Connors, Daniel; Steinsaltz, Matthew; DuBois, Wendy; Mock, Beverly A

The transcription factor MZF1 differentially regulates murine Mtor promoter variants linked to tumor susceptibility.

Zhang, Shuling; Shi, Wei; Ramsay, Edward S; Bliskovsky, Valery; Eiden, Adrian Max; Connors, Daniel; Steinsaltz, Matthew; DuBois, Wendy; Mock, Beverly A.

Afiliação

Zhang S; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892.
Shi W; Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, Maryland 20892.
Ramsay ES; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892.
Bliskovsky V; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892.
Eiden AM; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892.
Connors D; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892.
Steinsaltz M; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892.
DuBois W; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892.
Mock BA; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892 mockb@mail.nih.gov.

J Biol Chem ; 294(45): 16756-16764, 2019 11 08.

Article em En | MEDLINE | ID: mdl-31548308

Assuntos

Predisposição Genética para Doença/genética; Fatores de Transcrição Kruppel-Like/metabolismo; Mutação; Plasmocitoma/genética; Regiões Promotoras Genéticas/genética; Serina-Treonina Quinases TOR/genética; Alelos; Animais; Sequência de Bases; Linhagem Celular Tumoral; Regulação para Baixo; Camundongos; Plasmocitoma/patologia

Palavras-chave

B cells; Mtor promoter; SCAN-zinc finger (SCAN-ZF) transcription factor; general transcription factor (GTF); genetic polymorphism; mammalian target of rapamycin (mTOR); myeloid zinc finger protein 1 (MZF1); plasmacytoma; single-nucleotide polymorphism (SNP); transcription regulation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmocitoma / Regiões Promotoras Genéticas / Predisposição Genética para Doença / Fatores de Transcrição Kruppel-Like / Serina-Treonina Quinases TOR / Mutação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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