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A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3.
Dupont, Christian; Chen, Yushu; Xu, Zhujun; Roquet-Banères, Françoise; Blaise, Mickaël; Witt, Anne-Kathrin; Dubar, Faustine; Biot, Christophe; Guérardel, Yann; Maurer, Florian P; Chng, Shu-Sin; Kremer, Laurent.
Afiliação
  • Dupont C; Centre National de la Recherche Scientifique UMR9004, Institut de Recherche en Infectiologie de Montpellier, Université de Montpellier, 34293 Montpellier, France.
  • Chen Y; Department of Chemistry, National University of Singapore, Singapore 117543.
  • Xu Z; Department of Chemistry, National University of Singapore, Singapore 117543.
  • Roquet-Banères F; Centre National de la Recherche Scientifique UMR9004, Institut de Recherche en Infectiologie de Montpellier, Université de Montpellier, 34293 Montpellier, France.
  • Blaise M; Centre National de la Recherche Scientifique UMR9004, Institut de Recherche en Infectiologie de Montpellier, Université de Montpellier, 34293 Montpellier, France.
  • Witt AK; National Reference Center for Mycobacteria, Research Center Borstel-Leibniz Lung Center, D-23845 Borstel, Germany.
  • Dubar F; University of Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France.
  • Biot C; University of Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France.
  • Guérardel Y; University of Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France.
  • Maurer FP; National Reference Center for Mycobacteria, Research Center Borstel-Leibniz Lung Center, D-23845 Borstel, Germany.
  • Chng SS; Department of Chemistry, National University of Singapore, Singapore 117543 chmchngs@nus.edu.sg.
  • Kremer L; Centre National de la Recherche Scientifique UMR9004, Institut de Recherche en Infectiologie de Montpellier, Université de Montpellier, 34293 Montpellier, France laurent.kremer@irim.cnrs.fr.
J Biol Chem ; 294(46): 17512-17523, 2019 11 15.
Article em En | MEDLINE | ID: mdl-31562241
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Proteínas de Bactérias / Mycobacterium tuberculosis / Ácidos Micólicos / Antituberculosos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: França
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Proteínas de Bactérias / Mycobacterium tuberculosis / Ácidos Micólicos / Antituberculosos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: França