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Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.
Sakofsky, Cynthia J; Saini, Natalie; Klimczak, Leszek J; Chan, Kin; Malc, Ewa P; Mieczkowski, Piotr A; Burkholder, Adam B; Fargo, David; Gordenin, Dmitry A.
Afiliação
  • Sakofsky CJ; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America.
  • Saini N; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America.
  • Klimczak LJ; Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America.
  • Chan K; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America.
  • Malc EP; Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.
  • Mieczkowski PA; Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.
  • Burkholder AB; Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America.
  • Fargo D; Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America.
  • Gordenin DA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America.
PLoS Biol ; 17(9): e3000464, 2019 09.
Article em En | MEDLINE | ID: mdl-31568516
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mutagênese / Genoma Fúngico / Quebras de DNA de Cadeia Dupla / Neoplasias Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: PLoS Biol Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mutagênese / Genoma Fúngico / Quebras de DNA de Cadeia Dupla / Neoplasias Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: PLoS Biol Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos