In vitro study of Fc-receptor function in autoimmune diseases.
Immunol Lett
; 9(1): 53-6, 1985.
Article
em En
| MEDLINE
| ID: mdl-3157644
ABSTRACT
A simple test for studying in vitro Fc-receptor function of mononuclear phagocytes is described. Immune phagocytosis is analyzed as a dynamic phenomenon by using nearly pure suspensions of monocytes incubated for diverse times with autologous erythrocytes sensitized with highly purified IgG. In a series of normal volunteers and patients with vasculitis a strict correlation has been found between this in vitro assay and the measure of splenic clearance of IgG-coated red blood cells (RBC), the classical approach for studying in vivo macrophage Fc-receptor function by using sodium chromate 51Cr as tag. The use of this in vitro assay appears to be valuable mainly in cases requiring repeated measurements of Fc-receptor function for monitoring the course of disease or the effects of therapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fagocitose
/
Doenças Autoimunes
/
Monócitos
/
Receptores Fc
Limite:
Humans
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
1985
Tipo de documento:
Article