Future prospects for CD8+ regulatory T cells in immune tolerance.
Immunol Rev
; 292(1): 209-224, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31593314
ABSTRACT
CD8+ Tregs have been long described and significant progresses have been made about their phenotype, their functional mechanisms, and their suppressive ability compared to conventional CD4+ Tregs. They are now at the dawn of their clinical use. In this review, we will summarize their phenotypic characteristics, their mechanisms of action, the similarities, differences and synergies between CD8+ and CD4+ Tregs, and we will discuss the biology, development and induction of CD8+ Tregs, their manufacturing for clinical use, considering open questions/uncertainties and future technically accessible improvements notably through genetic modifications.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
/
Linfócitos T Reguladores
/
Linfócitos T CD8-Positivos
/
Tolerância Imunológica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Immunol Rev
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
França