α-Synuclein RT-QuIC assay in cerebrospinal fluid of patients with dementia with Lewy bodies.
Ann Clin Transl Neurol
; 6(10): 2120-2126, 2019 10.
Article
em En
| MEDLINE
| ID: mdl-31599499
ABSTRACT
We applied RT-QuIC assay to detect α-synuclein aggregates in cerebrospinal fluid (CSF) of patients with suspected Creutzfeldt-Jakob disease who had a neuropathological diagnosis of dementia with Lewy bodies (DLB) (n = 7), other neurodegenerative diseases with α-synuclein mixed pathology (n = 20), or without Lewy-related pathology (n = 49). The test had a sensitivity of 92.9% and specificity of 95.9% in distinguishing α-synucleinopathies from non-α-synucleinopathies. When performed in the CSF of patients with DLB (n = 36), RT-QuIC was positive in 17/20 with probable DLB, 0/6 with possible DLB, and 0/10 with Alzheimer disease. These results indicate that RT-QuIC for α-synuclein is an accurate test for DLB diagnosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bioensaio
/
Síndrome de Creutzfeldt-Jakob
/
Doença por Corpos de Lewy
/
Alfa-Sinucleína
/
Doença de Alzheimer
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Ann Clin Transl Neurol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Itália