Emtricitabine-induced pure red cell aplasia.
South Afr J HIV Med
; 20(1): 983, 2019.
Article
em En
| MEDLINE
| ID: mdl-31616574
ABSTRACT
INTRODUCTION:
Anemia is common in HIV. Parvo B19 infection is a well-recognised cause of red cell aplasia. Other causes of persistent pure red cell aplasia (PRCA) include anti-retroviral drugs such as zidovudine and lamivudine. We describe a case of PRCA that strongly implicates emtricitabine as the probable cause. PATIENT PRESENTATION Patient was HIV positive and on treatment with a fixed drug combination consisting of tenofovir, emtricitabine and efavirenz for 3 months when she developed severe transfusion dependent anemia. The anemia, attributed to PRCA, was persistent and transfusion dependent for about one year. MANAGEMENT ANDOUTCOME:
Replacement of emtricitabine with abacavir resulted in a prompt, complete and lasting resolution of the anaemia, suggesting an etiologic role of emtricitabine in the PRCA.CONCLUSION:
Emtricitibine is a rare cause of pure red cell aplasia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
South Afr J HIV Med
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
África do Sul