The synergetic effect of childhood trauma and recent stressful events in psychosis: associated neurocognitive dysfunction.
Acta Psychiatr Scand
; 141(1): 43-51, 2020 01.
Article
em En
| MEDLINE
| ID: mdl-31618440
ABSTRACT
BACKGROUND:
A higher incidence of childhood trauma (CT) has been reported in first episode of psychosis (FEP). There is, however, a lack of knowledge about the synergetic effect between CT and recent stressful events (RSE).METHODS:
Information on specific types of CT (under 17 years) and RSE (within the past 3 years) was available for 290 FEP patients and 52 healthy controls (HC). Cognitive function at baseline was assessed through a comprehensive neuropsychological test battery.RESULTS:
While 45.2% of FEP patients and 25% of HC reported at least one CT event, 62.7% of FEP and 21.2% of HC reported an RSE. Meanwhile, 36.2% of FEP patients and 9.6% of HC encountered both childhood and recent stressful events. The patients that just reported CT showed normality in all but the verbal memory cognitive domain; those with additive CT and RSE presented worse general cognitive function, specifically on working memory, processing speed, and executive function. RSE and general cognitive dysfunction were significant determinants of psychosis onset.CONCLUSIONS:
These results support a synergetic influence of trauma and stressful events on brain function and allow a better understanding of mediators for psychotic disorders useful in the design of specific strategies based on stress-targeted therapies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
/
Estresse Psicológico
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Disfunção Cognitiva
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Trauma Psicológico
/
Experiências Adversas da Infância
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Memória de Curto Prazo
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Acta Psychiatr Scand
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Espanha