Characterization of resistance to a potent D-peptide HIV entry inhibitor.

Smith, Amanda R; Weinstock, Matthew T; Siglin, Amanda E; Whitby, Frank G; Francis, J Nicholas; Hill, Christopher P; Eckert, Debra M; Root, Michael J; Kay, Michael S

Smith, Amanda R; Weinstock, Matthew T; Siglin, Amanda E; Whitby, Frank G; Francis, J Nicholas; Hill, Christopher P; Eckert, Debra M; Root, Michael J; Kay, Michael S.

Afiliação

Smith AR; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
Weinstock MT; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
Siglin AE; Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Whitby FG; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
Francis JN; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
Hill CP; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
Eckert DM; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
Root MJ; Department of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
Kay MS; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA. kay@biochem.utah.edu.

Retrovirology ; 16(1): 28, 2019 10 22.

Article em En | MEDLINE | ID: mdl-31640718

Assuntos

Fármacos Anti-HIV/farmacologia; Farmacorresistência Viral/genética; HIV-1/efeitos dos fármacos; Peptídeos/farmacologia; Internalização do Vírus/efeitos dos fármacos; Linhagem Celular; Infecções por HIV/virologia; HIV-1/genética; Humanos; Mutação

Palavras-chave

Compensatory mutation; D-peptide; HIV entry inhibition; Hydrophobic pocket; PIE12-trimer; Viral fitness; Viral passaging; Viral resistance mutation; gp120; gp41

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / HIV-1 / Fármacos Anti-HIV / Farmacorresistência Viral / Internalização do Vírus Limite: Humans Idioma: En Revista: Retrovirology Assunto da revista: VIROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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