Retinal vessel caliber and caliber responses in true normotensive black and white adults: The African-PREDICT study.
Microvasc Res
; 128: 103937, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-31644892
ABSTRACT
PURPOSE:
Globally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis of systemic vascular diseases, but it is unclear whether retinal vessel calibers and acute retinal vessel functional responses differ between young healthy black and white adults.METHODS:
We included 112 black and 143 white healthy normotensive adults (20-30â¯years). Retinal vessel calibers (central retinal artery and vein equivalent (CRAE and CRVE)) were calculated from retinal images and vessel caliber responses to flicker light induced provocation (FLIP) were determined. Additionally, ambulatory blood pressure (BP), anthropometry and blood samples were collected.RESULTS:
The groups displayed similar 24â¯h BP profiles and anthropometry (all pâ¯>â¯.24). Black participants demonstrated a smaller CRAE (158⯱â¯11 vs. 164⯱â¯11 MU, pâ¯<â¯.001) compared to the white group, whereas CRVE was similar (pâ¯=â¯.57). In response to FLIP, artery maximal dilation was greater in the black vs. white group (5.6⯱â¯2.1 vs. 3.3⯱â¯1.8%; pâ¯<â¯.001).CONCLUSIONS:
Already at a young age, healthy black adults showed narrower retinal arteries relative to the white population. Follow-up studies are underway to show if this will be related to increased risk for hypertension development. The reason for the larger vessel dilation responses to FLIP in the black population is unclear and warrants further investigation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artéria Retiniana
/
Veia Retiniana
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Vasodilatação
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Pressão Sanguínea
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População Negra
/
População Branca
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
Microvasc Res
Ano de publicação:
2020
Tipo de documento:
Article