Splicing factor DHX15 affects tp53 and mdm2 expression via alternate splicing and promoter usage.

McElderry, John; Carrington, Blake; Bishop, Kevin; Kim, Erika; Pei, Wuhong; Chen, Zelin; Ramanagoudr-Bhojappa, Ramanagouda; Prakash, Anupam; Burgess, Shawn M; Liu, P Paul; Sood, Raman

McElderry, John; Carrington, Blake; Bishop, Kevin; Kim, Erika; Pei, Wuhong; Chen, Zelin; Ramanagoudr-Bhojappa, Ramanagouda; Prakash, Anupam; Burgess, Shawn M; Liu, P Paul; Sood, Raman.

Afiliação

McElderry J; Zebrafish Core, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Carrington B; Zebrafish Core, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Bishop K; Zebrafish Core, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Kim E; Oncogenesis and Development Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Pei W; Developmental Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Chen Z; Developmental Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Ramanagoudr-Bhojappa R; Cancer Genomics Unit, Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Prakash A; Zebrafish Core, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Burgess SM; Developmental Genomics Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Liu PP; Oncogenesis and Development Section, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Sood R; Zebrafish Core, Translational and Functional Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Hum Mol Genet ; 28(24): 4173-4185, 2019 12 15.

Article em En | MEDLINE | ID: mdl-31691804

Assuntos

Proteínas Proto-Oncogênicas c-mdm2/genética; RNA Helicases/genética; Proteína Supressora de Tumor p53/genética; Proteínas de Peixe-Zebra/genética; Processamento Alternativo; Animais; Animais Geneticamente Modificados; Humanos; Regiões Promotoras Genéticas; Isoformas de Proteínas; Proteínas Proto-Oncogênicas c-mdm2/biossíntese; Proteínas Proto-Oncogênicas c-mdm2/metabolismo; RNA Helicases/metabolismo; Sítios de Splice de RNA; Splicing de RNA; Fatores de Processamento de RNA/genética; Sítio de Iniciação de Transcrição; Ativação Transcricional; Proteína Supressora de Tumor p53/metabolismo; Peixe-Zebra; Proteínas de Peixe-Zebra/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / RNA Helicases / Proteínas de Peixe-Zebra / Proteínas Proto-Oncogênicas c-mdm2 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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