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No Evidence for Social Genetic Effects or Genetic Similarity Among Friends Beyond that Due to Population Stratification: A Reappraisal of Domingue et al (2018).
Yengo, Loic; Sidari, Morgan; Verweij, Karin J H; Visscher, Peter M; Keller, Matthew C; Zietsch, Brendan P.
Afiliação
  • Yengo L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia.
  • Sidari M; School of Psychology, The University of Queensland, Brisbane, 4072, Australia.
  • Verweij KJH; Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
  • Visscher PM; Institute for Molecular Bioscience, The University of Queensland, Brisbane, 4072, Australia.
  • Keller MC; Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.
  • Zietsch BP; Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA.
Behav Genet ; 50(1): 67-71, 2020 01.
Article em En | MEDLINE | ID: mdl-31713005
Using data from 5500 adolescents from the National Longitudinal Study of Adolescent to Adult Health, Domingue et al. (Proc Natl Acad Sci 25:256., 2018) claimed to show that friends are genetically more similar to one another than randomly selected peers, beyond the confounding effects of population stratification by ancestry. The authors also claimed to show 'social-genetic' effects, whereby individuals' educational attainment (EA) is influenced by their friends' genes. We argue that neither claim is justified by the data. Mathematically we show that (1) the genetic similarity reported between friends is far larger than theoretically possible if it was caused by phenotypic assortment as the authors claim; uncontrolled population stratification is a likely reason for the genetic similarity they observed, and (2) significant association between individuals' EA and their friends' polygenic scores for EA is a necessary consequence of EA similarity among friends, and does not provide evidence for social-genetic effects. Going forward, we urge caution in the analysis and interpretation of data at the intersection of human genetics and the social sciences.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento do Adolescente / Amigos / Genótipo Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Female / Humans / Male Idioma: En Revista: Behav Genet Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento do Adolescente / Amigos / Genótipo Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Female / Humans / Male Idioma: En Revista: Behav Genet Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália