Biallelic PTCH1 Inactivation Is a Dominant Genomic Change in Sporadic Keratocystic Odontogenic Tumors.

Stojanov, Ivan J; Schaefer, Inga-Marie; Menon, Reshma S; Wasman, Jay; Gokozan, Hamza N; Garcia, Elizabeth P; Baur, Dale A; Woo, Sook-Bin; Sholl, Lynette M

Stojanov, Ivan J; Schaefer, Inga-Marie; Menon, Reshma S; Wasman, Jay; Gokozan, Hamza N; Garcia, Elizabeth P; Baur, Dale A; Woo, Sook-Bin; Sholl, Lynette M.

Afiliação

Stojanov IJ; Departments of Oral and Maxillofacial Medicine.
Schaefer IM; Department of Pathology, Case Western Reserve University School of Medicine.
Menon RS; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School.
Wasman J; Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston.
Gokozan HN; Department of Pathology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.
Garcia EP; Department of Pathology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.
Baur DA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School.
Woo SB; Oral and Maxillofacial Surgery, Case Western Reserve University School of Dental Medicine.
Sholl LM; Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston.

Am J Surg Pathol ; 44(4): 553-560, 2020 04.

Article em En | MEDLINE | ID: mdl-31725470

Assuntos

Biomarcadores Tumorais/genética; Inativação Gênica; Neoplasias Mandibulares/genética; Neoplasias Maxilares/genética; Mutação; Cistos Odontogênicos/genética; Tumores Odontogênicos/genética; Receptor Patched-1/genética; Adolescente; Adulto; Idoso; Idoso de 80 Anos ou mais; Criança; Análise Mutacional de DNA; Feminino; Predisposição Genética para Doença; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Masculino; Neoplasias Mandibulares/patologia; Neoplasias Maxilares/patologia; Pessoa de Meia-Idade; Cistos Odontogênicos/patologia; Tumores Odontogênicos/patologia; Fenótipo; Estudos Retrospectivos; Adulto Jovem

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Mandibulares / Neoplasias Maxilares / Cistos Odontogênicos / Tumores Odontogênicos / Biomarcadores Tumorais / Inativação Gênica / Receptor Patched-1 / Mutação Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Surg Pathol Ano de publicação: 2020 Tipo de documento: Article

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