Roseltide rT7 is a disulfide-rich, anionic, and cell-penetrating peptide that inhibits proteasomal degradation.

Kam, Antony; Loo, Shining; Fan, Jing-Song; Sze, Siu Kwan; Yang, Daiwen; Tam, James P

Kam, Antony; Loo, Shining; Fan, Jing-Song; Sze, Siu Kwan; Yang, Daiwen; Tam, James P.

Afiliação

Kam A; School of Biological Sciences, Nanyang Technological University, Singapore 637551.
Loo S; School of Biological Sciences, Nanyang Technological University, Singapore 637551.
Fan JS; Department of Biological Sciences, National University of Singapore, Singapore 117543.
Sze SK; School of Biological Sciences, Nanyang Technological University, Singapore 637551.
Yang D; Department of Biological Sciences, National University of Singapore, Singapore 117543.
Tam JP; School of Biological Sciences, Nanyang Technological University, Singapore 637551 JPTam@ntu.edu.sg.

J Biol Chem ; 294(51): 19604-19615, 2019 12 20.

Article em En | MEDLINE | ID: mdl-31727740

Assuntos

Peptídeos Penetradores de Células/farmacologia; Hibiscus/química; Extratos Vegetais/química; Complexo de Endopeptidases do Proteassoma/metabolismo; Inibidores de Proteassoma/farmacologia; Células A549; Anti-Inflamatórios/farmacologia; Peptídeos Catiônicos Antimicrobianos; Antineoplásicos Fitogênicos/farmacologia; Cisteína/química; Dissulfetos; Endocitose; Citometria de Fluxo; Humanos; Espectroscopia de Ressonância Magnética; Microscopia Confocal; Conformação Molecular; Lectinas de Plantas; Proteínas de Plantas/química; Proteômica; Relação Estrutura-Atividade; Ubiquitina/química

Palavras-chave

Hibiscus sabdariffa; cell-penetrating peptide (CPP); cystine-knot peptide; drug action; drug discovery; enzyme inhibitor; natural product; peptide chemical synthesis; peptides; plant peptide; protease inhibitor; proteasome; proteasome inhibitor; roseltide rT7; structure-function

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Hibiscus / Complexo de Endopeptidases do Proteassoma / Peptídeos Penetradores de Células / Inibidores de Proteassoma Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article

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