Dysregulation of FGFR signalling by a selective inhibitor reduces germ cell survival in human fetal gonads of both sexes and alters the somatic niche in fetal testes.

Harpelunde Poulsen, K; Nielsen, J E; Frederiksen, H; Melau, C; Juul Hare, K; Langhoff Thuesen, L; Perlman, S; Lundvall, L; Mitchell, R T; Juul, A; Rajpert-De Meyts, E; Jørgensen, A

Harpelunde Poulsen, K; Nielsen, J E; Frederiksen, H; Melau, C; Juul Hare, K; Langhoff Thuesen, L; Perlman, S; Lundvall, L; Mitchell, R T; Juul, A; Rajpert-De Meyts, E; Jørgensen, A.

Afiliação

Harpelunde Poulsen K; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, 2100 Copenhagen, Denmark.
Nielsen JE; International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Blegdamsvej 9, 2100 Copenhagen, Denmark.
Frederiksen H; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, 2100 Copenhagen, Denmark.
Melau C; International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Blegdamsvej 9, 2100 Copenhagen, Denmark.
Juul Hare K; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, 2100 Copenhagen, Denmark.
Langhoff Thuesen L; International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Blegdamsvej 9, 2100 Copenhagen, Denmark.
Perlman S; Department of Growth and Reproduction, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, 2100 Copenhagen, Denmark.
Lundvall L; International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Blegdamsvej 9, 2100 Copenhagen, Denmark.
Mitchell RT; Department of Obstetrics and Gynaecology, Hvidovre University Hospital, Kettegård Alle 30, 2650 Hvidovre, Denmark.
Juul A; Department of Obstetrics and Gynaecology, Hvidovre University Hospital, Kettegård Alle 30, 2650 Hvidovre, Denmark.
Rajpert-De Meyts E; Department of Gynaecology, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, Copenhagen 2100, Denmark.
Jørgensen A; Department of Gynaecology, Copenhagen University Hospital (Rigshospitalet), Blegdamsvej 9, Copenhagen 2100, Denmark.

Hum Reprod ; 34(11): 2228-2243, 2019 11 01.

Article em En | MEDLINE | ID: mdl-31734698

Assuntos

Regulação da Expressão Gênica no Desenvolvimento; Células Germinativas/efeitos dos fármacos; Ovário/embriologia; Receptor Tipo 1 de Fator de Crescimento de Fibroblastos/metabolismo; Testículo/embriologia; Diferenciação Celular; Linhagem da Célula; Proliferação de Células; Sobrevivência Celular; Feminino; Fator 9 de Crescimento de Fibroblastos/metabolismo; Humanos; Células Intersticiais do Testículo/efeitos dos fármacos; Masculino; Gravidez; Primeiro Trimestre da Gravidez; Pirróis/farmacologia; Receptor Tipo 1 de Fator de Crescimento de Fibroblastos/antagonistas & inibidores; Células de Sertoli/efeitos dos fármacos; Transdução de Sinais; Proteína Wnt4/metabolismo

Palavras-chave

human fetal testis / human fetal ovary / ex vivo culture / FGF9 signalling / gonocytes / oogonia / gonadal sex differentiation / initiation of meiosis / somatic niche formation

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ovário / Testículo / Regulação da Expressão Gênica no Desenvolvimento / Receptor Tipo 1 de Fator de Crescimento de Fibroblastos / Células Germinativas Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male / Pregnancy Idioma: En Revista: Hum Reprod Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Dinamarca

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google