Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins.

Khelashvili, George; Cheng, Xiaolu; Falzone, Maria E; Doktorova, Milka; Accardi, Alessio; Weinstein, Harel

Khelashvili, George; Cheng, Xiaolu; Falzone, Maria E; Doktorova, Milka; Accardi, Alessio; Weinstein, Harel.

Afiliação

Khelashvili G; Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York, 10065.
Cheng X; Institute for Computational Biomedicine, Weill Cornell Medical College of Cornell University, New York, New York, 10065.
Falzone ME; Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York, 10065.
Doktorova M; Department of Biochemistry, Weill Cornell Medical College of Cornell University, New York, New York, 10065.
Accardi A; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, Texas, 77030.
Weinstein H; Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, New York, 10065.

J Comput Chem ; 41(6): 538-551, 2020 03 05.

Article em En | MEDLINE | ID: mdl-31750558

Assuntos

Anoctaminas/química; Lipídeos de Membrana/química; Proteínas de Transferência de Fosfolipídeos/química; Anoctaminas/metabolismo; Lipídeos de Membrana/metabolismo; Simulação de Dinâmica Molecular; Proteínas de Transferência de Fosfolipídeos/metabolismo

Palavras-chave

CTMD method; cryo-EM structure determination; functional mechanisms of TMEM16 scramblases; lipid nanodiscs; lipid-dependent gating of TMEM16 scramblases; membrane remodeling; molecular dynamics (MD) simulation; phospholipid scramblases; protein-membrane interactions; time-structure Independent Component Analysis (tICA)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Transferência de Fosfolipídeos / Anoctaminas / Lipídeos de Membrana Idioma: En Revista: J Comput Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article

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