Induction of HLA-A2 restricted CD8 T cell responses against ApoB100 peptides does not affect atherosclerosis in a humanized mouse model.

Schaftenaar, Frank H; Amersfoort, Jacob; Douna, Hidde; Kröner, Mara J; Foks, Amanda C; Bot, Ilze; Slütter, Bram A; van Puijvelde, Gijs H M; Drijfhout, Jan W; Kuiper, Johan

Schaftenaar, Frank H; Amersfoort, Jacob; Douna, Hidde; Kröner, Mara J; Foks, Amanda C; Bot, Ilze; Slütter, Bram A; van Puijvelde, Gijs H M; Drijfhout, Jan W; Kuiper, Johan.

Afiliação

Schaftenaar FH; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden, The Netherlands. f.h.schaftenaar@lacdr.leidenuniv.nl.
Amersfoort J; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden, The Netherlands.
Douna H; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden, The Netherlands.
Kröner MJ; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden, The Netherlands.
Foks AC; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden, The Netherlands.
Bot I; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden, The Netherlands.
Slütter BA; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden, The Netherlands.
van Puijvelde GHM; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden, The Netherlands.
Drijfhout JW; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.
Kuiper J; Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden, The Netherlands. j.kuiper@lacdr.leidenuniv.nl.

Sci Rep ; 9(1): 17391, 2019 11 22.

Article em En | MEDLINE | ID: mdl-31757993

Assuntos

Apolipoproteína B-100/imunologia; Aterosclerose/imunologia; Linfócitos T CD8-Positivos/imunologia; Antígeno HLA-A2/imunologia; Animais; Anticorpos Monoclonais Humanizados/metabolismo; Apolipoproteína B-100/química; Aterosclerose/genética; Aterosclerose/patologia; Células Cultivadas; Modelos Animais de Doenças; Epitopos de Linfócito T/imunologia; Antígeno HLA-A2/genética; Antígeno HLA-A2/metabolismo; Humanos; Ativação Linfocitária; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Peptídeos/imunologia; Receptores de LDL/genética; Receptores de LDL/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígeno HLA-A2 / Linfócitos T CD8-Positivos / Aterosclerose / Apolipoproteína B-100 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda

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