Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin.

Juni, Rio P; Kuster, Diederik W D; Goebel, Max; Helmes, Michiel; Musters, René J P; van der Velden, Jolanda; Koolwijk, Pieter; Paulus, Walter J; van Hinsbergh, Victor W M

Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin.

Juni, Rio P; Kuster, Diederik W D; Goebel, Max; Helmes, Michiel; Musters, René J P; van der Velden, Jolanda; Koolwijk, Pieter; Paulus, Walter J; van Hinsbergh, Victor W M.

Afiliação

Juni RP; Amsterdam Cardiovascular Sciences, Department of Physiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Kuster DWD; Amsterdam Cardiovascular Sciences, Department of Physiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Goebel M; Amsterdam Cardiovascular Sciences, Department of Physiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Helmes M; Amsterdam Cardiovascular Sciences, Department of Physiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Musters RJP; CytoCypher B.V., Wageningen, the Netherlands.
van der Velden J; Amsterdam Cardiovascular Sciences, Department of Physiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Koolwijk P; Amsterdam Cardiovascular Sciences, Department of Physiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
Paulus WJ; Netherlands Heart Institute, Utrecht, the Netherlands.
van Hinsbergh VWM; Amsterdam Cardiovascular Sciences, Department of Physiology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.

JACC Basic Transl Sci ; 4(5): 575-591, 2019 Sep.

Article em En | MEDLINE | ID: mdl-31768475

Palavras-chave

CM, cardiomyocyte; CMEC, cardiac microvascular endothelial cell; Ca, calcium; DM, diabetes mellitus; DPPH, 1,1-diphenyl-picrylhydrazyl; EC, endothelial cell; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; JNK, Jun N-terminal kinase; L-NAME, N(ω)-nitro-L-arginine methyl ester; LV, left ventricular; NK-κB, nuclear factor-κB; NO, nitric oxide; ROS, reactive oxygen species; SGLT2, sodium glucose transporter 2; contraction and relaxation; eNOS, endothelial nitric oxide synthase; empagliflozin; endothelial cellderived nitric oxide; heart failure; oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials Idioma: En Revista: JACC Basic Transl Sci Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Holanda

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