Subacute dermal toxicity of perfluoroalkyl carboxylic acids: comparison with different carbon-chain lengths in human skin equivalents and systemic effects of perfluoroheptanoic acid in Sprague Dawley rats.

Han, Ji-Seok; Jang, Sumi; Son, Hwa-Young; Kim, Yong-Bum; Kim, Younhee; Noh, Jung-Ho; Kim, Mi-Jeong; Lee, Byoung-Seok

Han, Ji-Seok; Jang, Sumi; Son, Hwa-Young; Kim, Yong-Bum; Kim, Younhee; Noh, Jung-Ho; Kim, Mi-Jeong; Lee, Byoung-Seok.

Afiliação

Han JS; Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), 141 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea.
Jang S; Department of Veterinary Pathology, College of Medicine, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea.
Son HY; Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), 141 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea.
Kim YB; Department of Veterinary Pathology, College of Medicine, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea.
Kim Y; Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), 141 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea.
Noh JH; Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), 141 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea.
Kim MJ; Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), 141 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea.
Lee BS; Research Institute, T&R Biofab Co., Ltd., 242 Pangyo Digital Center, Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13487, Republic of Korea.

Arch Toxicol ; 94(2): 523-539, 2020 02.

Article em En | MEDLINE | ID: mdl-31797001

Assuntos

Ácidos Carboxílicos/toxicidade; Fluorocarbonos/toxicidade; Pele/citologia; Pele/efeitos dos fármacos; Testes de Toxicidade Subaguda/métodos; 8-Hidroxi-2'-Desoxiguanosina/metabolismo; Animais; Peso Corporal/efeitos dos fármacos; Ácidos Carboxílicos/química; Técnicas de Cultura de Células; Relação Dose-Resposta a Droga; Feminino; Fluorocarbonos/química; Ácidos Heptanoicos/toxicidade; Humanos; Interleucina-1alfa/metabolismo; Masculino; Ratos Sprague-Dawley; Espécies Reativas de Oxigênio/metabolismo; Pele/metabolismo; Relação Estrutura-Atividade

Palavras-chave

Dermal toxicity; Human skin equivalent (HSE); Per- and polyfluoroalkyl substances (PFASs); Perfluoroheptanoic acid (PFHpA); Perfluorooctanoic acid (PFOA); Short-chain perfluoroalkyl carboxylic acids (SC PFCAs)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pele / Ácidos Carboxílicos / Testes de Toxicidade Subaguda / Fluorocarbonos Limite: Animals / Female / Humans / Male Idioma: En Revista: Arch Toxicol Ano de publicação: 2020 Tipo de documento: Article

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