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Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis.
Dasgupta, Medhanjali; Budday, Dominik; de Oliveira, Saulo H P; Madzelan, Peter; Marchany-Rivera, Darya; Seravalli, Javier; Hayes, Brandon; Sierra, Raymond G; Boutet, Sébastien; Hunter, Mark S; Alonso-Mori, Roberto; Batyuk, Alexander; Wierman, Jennifer; Lyubimov, Artem; Brewster, Aaron S; Sauter, Nicholas K; Applegate, Gregory A; Tiwari, Virendra K; Berkowitz, David B; Thompson, Michael C; Cohen, Aina E; Fraser, James S; Wall, Michael E; van den Bedem, Henry; Wilson, Mark A.
Afiliação
  • Dasgupta M; Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, NE 68588.
  • Budday D; Chair of Applied Dynamics, Friedrich-Alexander University Erlangen-Nürnberg, 91058 Erlangen, Germany.
  • de Oliveira SHP; Bioengineering Department, Stanford University, Stanford, CA 94305.
  • Madzelan P; Bioscience Division, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
  • Marchany-Rivera D; Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, NE 68588.
  • Seravalli J; Chemistry Department, University of Puerto Rico, Mayagüez PR 00681.
  • Hayes B; Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, NE 68588.
  • Sierra RG; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
  • Boutet S; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
  • Hunter MS; Stanford PULSE Institute, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
  • Alonso-Mori R; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
  • Batyuk A; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
  • Wierman J; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
  • Lyubimov A; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
  • Brewster AS; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
  • Sauter NK; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
  • Applegate GA; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
  • Tiwari VK; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
  • Berkowitz DB; Department of Chemistry, University of Nebraska, Lincoln, NE 68588.
  • Thompson MC; Department of Chemistry, University of Nebraska, Lincoln, NE 68588.
  • Cohen AE; Department of Chemistry, University of Nebraska, Lincoln, NE 68588.
  • Fraser JS; Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biology, University of California, San Francisco, CA 94158.
  • Wall ME; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
  • van den Bedem H; Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biology, University of California, San Francisco, CA 94158.
  • Wilson MA; Computer, Computational, and Statistical Sciences Division, Los Alamos National Laboratory, Los Alamos, NM 87505.
Proc Natl Acad Sci U S A ; 116(51): 25634-25640, 2019 12 17.
Article em En | MEDLINE | ID: mdl-31801874
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cristalografia por Raios X / Enzimas Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cristalografia por Raios X / Enzimas Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article