Tetrahydroquinoline units in flexible heteroarotinoids (Flex-Hets) convey anti-cancer properties in A2780 ovarian cancer cells.

Gnanasekaran, Krishna Kumar; Pouland, Tim; Bunce, Richard A; Darrell Berlin, K; Abuskhuna, Suaad; Bhandari, Dipendra; Mashayekhi, Maryam; Zhou, Donghua H; Benbrook, Doris M

Gnanasekaran, Krishna Kumar; Pouland, Tim; Bunce, Richard A; Darrell Berlin, K; Abuskhuna, Suaad; Bhandari, Dipendra; Mashayekhi, Maryam; Zhou, Donghua H; Benbrook, Doris M.

Afiliação

Gnanasekaran KK; Department of Chemistry, Oklahoma State University, Stillwater, OK 74078, United States.
Pouland T; Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States.
Bunce RA; Department of Chemistry, Oklahoma State University, Stillwater, OK 74078, United States. Electronic address: rab@okstate.edu.
Darrell Berlin K; Department of Chemistry, Oklahoma State University, Stillwater, OK 74078, United States.
Abuskhuna S; Department of Chemistry, Oklahoma State University, Stillwater, OK 74078, United States.
Bhandari D; Department of Physics, Oklahoma State University, Stillwater, OK 74078, United States.
Mashayekhi M; Department of Physics, Oklahoma State University, Stillwater, OK 74078, United States.
Zhou DH; Department of Physics, Oklahoma State University, Stillwater, OK 74078, United States.
Benbrook DM; Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States.

Bioorg Med Chem ; 28(1): 115244, 2020 01 01.

Article em En | MEDLINE | ID: mdl-31831296

Assuntos

Antineoplásicos/química; Quinolinas/química; Antineoplásicos/farmacologia; Sítios de Ligação; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Cromanos/química; Cromanos/farmacologia; Feminino; Humanos; Simulação de Acoplamento Molecular; Neoplasias Ovarianas/metabolismo; Neoplasias Ovarianas/patologia; Quinolinas/farmacologia; Relação Estrutura-Atividade; Tionas/química; Tionas/farmacologia; Ureia/química

Palavras-chave

In silico docking study; Mortalin; SHetA2; Structure optimization; Tetrahydroquinoline-based anticancer agents

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinolinas / Antineoplásicos Limite: Female / Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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