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Perspectives in allergen immunotherapy: 2019 and beyond.
Pfaar, Oliver; Agache, Ioana; de Blay, Frédéric; Bonini, Sergio; Chaker, Adam M; Durham, Stephen R; Gawlik, Radoslaw; Hellings, Peter W; Jutel, Marek; Kleine-Tebbe, Jörg; Klimek, Ludger; Kopp, Matthias V; Nandy, Andreas; Rabin, Ronald L; van Ree, Ronald; Renz, Harald; Roberts, Graham; Salapatek, Anne-Marie; Schmidt-Weber, Carsten B; Shamji, Mohamed H; Sturm, Gunter J; Virchow, J Christian; Wahn, Ulrich; Willers, Christoph; Zieglmayer, Petra; Akdis, Cezmi A.
Afiliação
  • Pfaar O; Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
  • Agache I; Faculty of Medicine, Transylvania University, Brasov, Romania.
  • de Blay F; Pneumology Department, New Civil Hospital, Strasbourg-Cedex, France.
  • Bonini S; Institute of Translational Medicine, Italian National Research Council, Rome, Italy.
  • Chaker AM; Department of Otolaryngology and Center of Allergy and Environment, TUM School of Medicine, Technical University of Munich, Munich, Germany.
  • Durham SR; Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College London, London, UK.
  • Gawlik R; MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.
  • Hellings PW; Department of Internal Medicine, Allergology and Clinical Immunology, Silesian University of Medicine, Katowice, Poland.
  • Jutel M; Department of Otorhinolaryngology, University Hospitals of Leuven, Leuven, Belgium.
  • Kleine-Tebbe J; Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
  • Klimek L; Department of Neuroscience, University of Ghent, Ghent, Belgium.
  • Kopp MV; Department of Clinical Immunology, Wroclaw Medical University, Wroclaw, Poland.
  • Nandy A; All-Med Medical Research Institute, Wroclaw, Poland.
  • Rabin RL; Allergy & Asthma Center Westend, Outpatient Clinic and Clinical Research Center, Berlin, Germany.
  • van Ree R; Center for Rhinology and Allergology, Wiesbaden, Germany.
  • Renz H; Department of Pediatric Allergy and Pulmonology, University of Luebeck, Luebeck, Germany.
  • Roberts G; Member of the Deutsches Zentrum für Lungenforschung (DZL), Airway Research Center North (ARCN), Luebeck, Germany.
  • Salapatek AM; Research & Development, Allergopharma GmbH & Co. KG, Reinbek, Germany.
  • Schmidt-Weber CB; Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
  • Shamji MH; Departments of Experimental Immunology and of Otorhinolaryngology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
  • Sturm GJ; Department Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University Giessen and Philipps-Universität Marburg, Marburg, Germany.
  • Virchow JC; Paediatric Allergy and Respiratory Medicine, University of Southampton, Southampton, UK.
  • Wahn U; David Hide Asthma and Allergy Centre, St Mary's Hospital, Isle of Wight, UK.
  • Willers C; Inflamax Research DBA Cliantha Research, Mississauga, ON, Canada.
  • Zieglmayer P; Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, Munich, Germany.
  • Akdis CA; Member of the German Center for Lung Research (DZL), Lübeck, Germany.
Allergy ; 74 Suppl 108: 3-25, 2019 12.
Article em En | MEDLINE | ID: mdl-31872476
ABSTRACT
The seventh "Future of the Allergists and Specific Immunotherapy (FASIT)" workshop held in 2019 provided a platform for global experts from academia, allergy clinics, regulatory authorities and industry to review current developments in the field of allergen immunotherapy (AIT). Key domains of the meeting included the following (a) Biomarkers for AIT and allergic asthma; (b) visions for the future of AIT; (c) progress and data for AIT in asthma and the updates of GINA and EAACI Asthma Guidelines (separated for house dust mite SCIT, SLIT tablets and SLIT drops; patient populations) including a review of clinically relevant endpoints in AIT studies in asthma; (d) regulatory prerequisites such as the "Therapy Allergen Ordinance" in Germany; (e) optimization of trial design in AIT clinical research; (f) challenges planning and conducting phase III (field) studies and the future role of Allergen Exposure Chambers (AEC) in AIT product development from the regulatory point of view. We report a summary of panel discussions of all six domains and highlight unmet needs and possible solutions for the future.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Imunoterapia Sublingual / Rinite Alérgica Tipo de estudo: Guideline / Qualitative_research Limite: Animals / Humans Idioma: En Revista: Allergy Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Imunoterapia Sublingual / Rinite Alérgica Tipo de estudo: Guideline / Qualitative_research Limite: Animals / Humans Idioma: En Revista: Allergy Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha