Immunosuppressive withanolides from the flower of Datura metel L.
Fitoterapia
; 141: 104468, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-31887326
ABSTRACT
Thirteen new withanolide aglycones, baimantuoluolines L-X (1-13) and one new withanolide glycoside, baimantuoluoside J (14) were isolated from Datura metel L. flowers. The structures of the new compounds were elucidated by the detailed analysis of 1D and 2D NMR techniques and mass spectrometry, together with the closely related literatures. Meanwhile, all isolated compounds were evaluated for their immunosuppressive activities against mice splenocyte proliferation and antiproliferative activities against human gastric adenocarcinoma cells (SGC-7901), human hepatoma (HepG2), and human breast cancer (MCF-7) in vitro. It was found that compounds 1-14 showed obvious immunosupressive effects and some of them have moderated antiproliferative activities.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Folhas de Planta
/
Vitanolídeos
/
Datura metel
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China