Proliferation of alveolar macrophages in hyperoxia.
Ann Allergy
; 61(5): 344-7, 1988 Nov.
Article
em En
| MEDLINE
| ID: mdl-3189961
ABSTRACT
The effect of oxygen on the proliferative response of alveolar macrophages (AMs) was investigated. Alveolar macrophages cultured in hyperoxic atmosphere (95% O2 + 5% CO2) for 18 hours showed increased incorporation of [3H]-thymidine and proliferation in contrast to those cultured in a control atmosphere (95% air + 5% CO2). The proliferating cell was shown to be a macrophage by morphology, esterase staining, and phagocytic ability. The results suggest an oxygen-induced proliferation of AMs that may play a critical role in AM influx into the alveoli particularly at times of hyperoxia, eg, the neonatal period.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Alvéolos Pulmonares
/
Macrófagos
Limite:
Animals
Idioma:
En
Revista:
Ann Allergy
Ano de publicação:
1988
Tipo de documento:
Article