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Defining a cohort of oligometastatic nasopharyngeal carcinoma patients with improved clinical outcomes.
Chee, Jeremy; Liu, Xuandao; Eu, Donovan; Loh, Thomas; Ho, Francis; Wong, Lea C; Tham, Ivan; Tan, Chee S; Goh, Boon C; Lim, Chwee M.
Afiliação
  • Chee J; Department of Otolaryngology-Head and Neck Surgery, National University Health System, Singapore, Singapore.
  • Liu X; Department of Otolaryngology-Head and Neck Surgery, National University Health System, Singapore, Singapore.
  • Eu D; Department of Otolaryngology-Head and Neck Surgery, National University Health System, Singapore, Singapore.
  • Loh T; Department of Otolaryngology-Head and Neck Surgery, National University Health System, Singapore, Singapore.
  • Ho F; National University Cancer Institute, Singapore, Singapore.
  • Wong LC; National University Cancer Institute, Singapore, Singapore.
  • Tham I; National University Cancer Institute, Singapore, Singapore.
  • Tan CS; National University Cancer Institute, Singapore, Singapore.
  • Goh BC; National University Cancer Institute, Singapore, Singapore.
  • Lim CM; National University Cancer Institute, Singapore, Singapore.
Head Neck ; 42(5): 945-954, 2020 05.
Article em En | MEDLINE | ID: mdl-31909854
ABSTRACT

OBJECTIVES:

To compare the clinical outcomes of oligometastatic versus widely metastatic NPC patients. MATERIALS AND

METHODS:

Retrospective review of 157 patients with metastatic NPC at a tertiary hospital was performed. Multivariate analysis was carried out to compare the overall and progression-free survival (OS and PFS) of these two cohorts of NPC patients. The number of organ involvement and discrete metastatic lesions associated with improved OS and PFS were ascertained.

RESULTS:

Patients with oligometastatic NPC (single organ, less than six discrete metastatic lesions) had a better median OS than patients with widespread metastasis (24.8 versus 12.8 months, P < .001). Similarly, the median PFS of oligometastatic NPC was better than that of polymetastatic NPC (11.7 versus 7.3 months, P < .001).

CONCLUSION:

Single organ disease with less than six discrete lesions is a good indicator of limited metastatic load in NPC, and is associated with improved survival.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas Tipo de estudo: Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Head Neck Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Singapura

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas Tipo de estudo: Observational_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Head Neck Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Singapura