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Prenatal LPS induces sickness behaviour and decreases maternal and predatory behaviours after an LPS challenge.
Mendes-Lima, T; Kirsten, T B; Rodrigues, P S; Sampaio, A C S; Felício, L F; Rocha, P R D A; Reis-Silva, T M; Bondan, E F; Martins, M F M; Queiroz-Hazarbassanov, N; Bernardi, M M.
Afiliação
  • Mendes-Lima T; Graduate Program in Environmental and Experimental Pathology, Graduate Program in Dentistry, Paulista University, São Paulo, SP, Brazil.
  • Kirsten TB; Graduate Program in Environmental and Experimental Pathology, Graduate Program in Dentistry, Paulista University, São Paulo, SP, Brazil.
  • Rodrigues PS; Graduate Program in Environmental and Experimental Pathology, Graduate Program in Dentistry, Paulista University, São Paulo, SP, Brazil.
  • Sampaio ACS; Graduate Program in Environmental and Experimental Pathology, Graduate Program in Dentistry, Paulista University, São Paulo, SP, Brazil.
  • Felício LF; Department of Pathology, School of Veterinary Medicine, University of São Paulo, São Paulo, SP CEP, Brazil.
  • Rocha PRDA; Graduate Program in Environmental and Experimental Pathology, Graduate Program in Dentistry, Paulista University, São Paulo, SP, Brazil.
  • Reis-Silva TM; Graduate Program in Environmental and Experimental Pathology, Graduate Program in Dentistry, Paulista University, São Paulo, SP, Brazil.
  • Bondan EF; Graduate Program in Environmental and Experimental Pathology, Graduate Program in Dentistry, Paulista University, São Paulo, SP, Brazil.
  • Martins MFM; Graduate Program in Environmental and Experimental Pathology, Graduate Program in Dentistry, Paulista University, São Paulo, SP, Brazil.
  • Queiroz-Hazarbassanov N; Department of Pathology, School of Veterinary Medicine, University of São Paulo, São Paulo, SP CEP, Brazil.
  • Bernardi MM; Graduate Program in Environmental and Experimental Pathology, Graduate Program in Dentistry, Paulista University, São Paulo, SP, Brazil.
Int J Neurosci ; 130(8): 804-816, 2020 Aug.
Article em En | MEDLINE | ID: mdl-31916878
Purpose: The influence of a challenge dose of lipopolysaccharide (LPS) on the behavioural selection between maternal (MB) and predatory behaviours (PB) of female rats prenatally treated with the same endotoxin or saline solution (F1 generation) were studied.Material and methods: Thus, in adult age, these female rats were mated and, at lactation days 5 or 6, the following groups were formed: (1) LPS + LPS group-female rats prenatally treated with LPS and received an LPS challenge dose; (2) S + LPS group-female rats prenatally treated with saline solution and received a challenge LPS dose (3) S + S group-females rats prenatally treated with saline which received a saline injection. MB, PB to cockroaches, exploratory behaviour, periaqueductal grey (PAG) expression of the astrocytic biomarker glial fibrillary acidic protein (GFAP), and corticosterone and TNF-alpha serum levels were evaluated.Results: Showed that: (1) relative to the S + S group, the LPS + S group showed decreased MB and slightly increased PB, without inducing sickness behaviour; (2) the LPS + LPS group showed decreased MB but few effects on PB; (3) there was increased sickness behaviour associated with increased TNF-alpha serum levels in the LPS + LPS group; (4) a significant increase in GFAP expression was observed in both LPS groups, which was greater in the LPS + LPS group and (5) no differences in the corticosterone of all groups.Conclusions: Prenatal LPS impaired the switch from MB to PB in female rats of the LPS + LPS group by increased sickness behaviour as well as an increase in plasmatic TNF-alpha levels inducing PAG astrogliosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Predatório / Efeitos Tardios da Exposição Pré-Natal / Lipopolissacarídeos / Fator de Necrose Tumoral alfa / Comportamento de Doença / Proteína Glial Fibrilar Ácida / Gliose / Comportamento Materno Tipo de estudo: Prognostic_studies Limite: Animals / Pregnancy Idioma: En Revista: Int J Neurosci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento Predatório / Efeitos Tardios da Exposição Pré-Natal / Lipopolissacarídeos / Fator de Necrose Tumoral alfa / Comportamento de Doença / Proteína Glial Fibrilar Ácida / Gliose / Comportamento Materno Tipo de estudo: Prognostic_studies Limite: Animals / Pregnancy Idioma: En Revista: Int J Neurosci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil