Neuroprotective racemic germacranolides from the roots of Chloranthus henryi.
Fitoterapia
; 141: 104472, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-31917303
ABSTRACT
Three pairs of new germacranolides, (+)/(-)-chlogermacrones A-C, along with two known analogues were obtained from the roots of Chloranthus henryi. Spectroscopic techniques and single-crystal X-ray crystallographic analyses were used for the structure elucidation of the compounds. All of the isolated compounds were tested for their neuroprotective effects on H2O2 damaged PC12 cells, compounds 3 and 5 increased cell viability from 43.4 ± 1.3% to 99.6 ± 8.7 and 68.1 ± 4.8% at 10 µM, respectively.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Raízes de Plantas
/
Fármacos Neuroprotetores
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Magnoliopsida
Limite:
Animals
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2020
Tipo de documento:
Article