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Reduction of the therapeutic dose of silencing RNA by packaging it in extracellular vesicles via a pre-microRNA backbone.
Reshke, Ryan; Taylor, James A; Savard, Alexandre; Guo, Huishan; Rhym, Luke H; Kowalski, Piotr S; Trung, My Tran; Campbell, Charles; Little, Wheaton; Anderson, Daniel G; Gibbings, Derrick.
Afiliação
  • Reshke R; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.
  • Taylor JA; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Canada.
  • Savard A; Éric Poulin Center for Neuromuscular Disease, University of Ottawa, Ottawa, Canada.
  • Guo H; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.
  • Rhym LH; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Canada.
  • Kowalski PS; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.
  • Trung MT; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Canada.
  • Campbell C; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada.
  • Little W; Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Canada.
  • Anderson DG; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Gibbings D; The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nat Biomed Eng ; 4(1): 52-68, 2020 01.
Article em En | MEDLINE | ID: mdl-31937944
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / RNA Interferente Pequeno / Vesículas Extracelulares Limite: Animals / Humans Idioma: En Revista: Nat Biomed Eng Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / RNA Interferente Pequeno / Vesículas Extracelulares Limite: Animals / Humans Idioma: En Revista: Nat Biomed Eng Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá