Through Reducing ROS Production, IL-10 Suppresses Caspase-1-Dependent IL-1ß Maturation, thereby Preventing Chronic Neuroinflammation and Neurodegeneration.

Gao, Yun; Tu, Dezhen; Yang, Ru; Chu, Chun-Hsien; Hong, Jau-Shyong; Gao, Hui-Ming

Gao, Yun; Tu, Dezhen; Yang, Ru; Chu, Chun-Hsien; Hong, Jau-Shyong; Gao, Hui-Ming.

Afiliação

Gao Y; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Institute for Brain Sciences, Nanjing University, Nanjing 210061, China.
Tu D; Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC 27709, USA.
Yang R; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Institute for Brain Sciences, Nanjing University, Nanjing 210061, China.
Chu CH; Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC 27709, USA.
Hong JS; MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Institute for Brain Sciences, Nanjing University, Nanjing 210061, China.
Gao HM; Laboratory of Neurobiology, Division of Intramural Research, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, NC 27709, USA.

Int J Mol Sci ; 21(2)2020 Jan 11.

Article em En | MEDLINE | ID: mdl-31940754

Assuntos

Caspase 1/metabolismo; Neurônios Dopaminérgicos/metabolismo; Interleucina-10/metabolismo; Interleucina-1beta/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Animais; Células Cultivadas; Neurônios Dopaminérgicos/efeitos dos fármacos; Feminino; Interleucina-10/genética; Lipopolissacarídeos/toxicidade; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Microglia/efeitos dos fármacos; Microglia/metabolismo; NADPH Oxidase 2/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Substância Negra/citologia; Substância Negra/metabolismo

Palavras-chave

IL-10; IL-1ß; NLRP3 inflammasome; Parkinson's disease; ROS; neuroinflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-10 / Espécies Reativas de Oxigênio / Caspase 1 / Interleucina-1beta / Neurônios Dopaminérgicos Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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