Inhibition of inflammation-mediated DPP-4 expression by linagliptin increases M2 macrophages in atherosclerotic lesions.

Nishida, Shuhei; Matsumura, Takeshi; Senokuchi, Takafumi; Murakami-Nishida, Saiko; Ishii, Norio; Morita, Yutaro; Yagi, Yoshitaka; Motoshima, Hiroyuki; Kondo, Tatsuya; Araki, Eiichi

Inhibition of inflammation-mediated DPP-4 expression by linagliptin increases M2 macrophages in atherosclerotic lesions.

Nishida, Shuhei; Matsumura, Takeshi; Senokuchi, Takafumi; Murakami-Nishida, Saiko; Ishii, Norio; Morita, Yutaro; Yagi, Yoshitaka; Motoshima, Hiroyuki; Kondo, Tatsuya; Araki, Eiichi.

Afiliação

Nishida S; Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Matsumura T; Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. Electronic address: takeshim@gpo.kumamoto-u.ac.jp.
Senokuchi T; Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Murakami-Nishida S; Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Ishii N; Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Morita Y; Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Yagi Y; Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Motoshima H; Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Kondo T; Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Araki E; Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan; Center for Metabolic Regulation of Healthy Aging (CMHA), Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Biochem Biophys Res Commun ; 524(1): 8-15, 2020 03 26.

Article em En | MEDLINE | ID: mdl-31964532

Assuntos

Anti-Inflamatórios/química; Dipeptidil Peptidase 4/metabolismo; Inibidores da Dipeptidil Peptidase IV/química; Inflamação/tratamento farmacológico; Linagliptina/química; Animais; Anti-Inflamatórios/farmacologia; Aorta/metabolismo; Aterosclerose/tratamento farmacológico; Células da Medula Óssea/efeitos dos fármacos; Dieta Hiperlipídica; Dipeptidil Peptidase 4/genética; Inibidores da Dipeptidil Peptidase IV/farmacologia; Regulação da Expressão Gênica/efeitos dos fármacos; Humanos; Linagliptina/farmacologia; Macrófagos/citologia; Macrófagos/efeitos dos fármacos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Modelos Animais; RNA Mensageiro/metabolismo; RNA Interferente Pequeno/metabolismo

Palavras-chave

Atherosclerosis; DPP-4 inhibitor; Macrophage; Polarization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dipeptidil Peptidase 4 / Inibidores da Dipeptidil Peptidase IV / Linagliptina / Inflamação / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

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