Lead Optimization of Dehydroemetine for Repositioned Use in Malaria.

Panwar, Priyanka; Burusco, Kepa K; Abubaker, Muna; Matthews, Holly; Gutnov, Andrey; Fernández-Álvaro, Elena; Bryce, Richard A; Wilkinson, James; Nirmalan, Niroshini

Panwar, Priyanka; Burusco, Kepa K; Abubaker, Muna; Matthews, Holly; Gutnov, Andrey; Fernández-Álvaro, Elena; Bryce, Richard A; Wilkinson, James; Nirmalan, Niroshini.

Afiliação

Panwar P; Environment and Life Sciences, University of Salford, Greater Manchester, United Kingdom.
Burusco KK; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.
Abubaker M; Environment and Life Sciences, University of Salford, Greater Manchester, United Kingdom.
Matthews H; Keele University, Newcastle-under-Lyme, Staffordshire, United Kingdom.
Gutnov A; Chiroblock GMBH, Wolfen, Germany.
Fernández-Álvaro E; GlaxoSmithKline, Diseases of the Developing World Medicines Development Campus, Tres Cantos, Spain.
Bryce RA; Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.
Wilkinson J; Environment and Life Sciences, University of Salford, Greater Manchester, United Kingdom.
Nirmalan N; Environment and Life Sciences, University of Salford, Greater Manchester, United Kingdom n.j.nirmalan@salford.ac.uk.

Antimicrob Agents Chemother ; 64(4)2020 03 24.

Article em En | MEDLINE | ID: mdl-31964796

Assuntos

Antimaláricos/farmacologia; Reposicionamento de Medicamentos; Emetina/análogos & derivados; Malária Falciparum/tratamento farmacológico; Plasmodium falciparum/efeitos dos fármacos; Antimaláricos/efeitos adversos; Atovaquona/farmacologia; Linhagem Celular Tumoral; Resistência a Múltiplos Medicamentos/genética; Sinergismo Farmacológico; Emetina/efeitos adversos; Emetina/química; Emetina/farmacologia; Feminino; Células Hep G2; Humanos; Masculino; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Plasmodium falciparum/genética; Proguanil/farmacologia; Estereoisomerismo

Palavras-chave

SYBR green flow cytometry; antimalarial drug interactions; dehydroemetine; drug discovery; emetine; malaria; repositioning

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Malária Falciparum / Emetina / Reposicionamento de Medicamentos / Antimaláricos Limite: Female / Humans / Male Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido

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