Fluorinated &#945;-Helical Polypeptides Synchronize Mucus Permeation and Cell Penetration toward Highly Efficient Pulmonary siRNA Delivery against Acute Lung Injury.

Ge, Chenglong; Yang, Jiandong; Duan, Shanzhou; Liu, Yong; Meng, Fenghua; Yin, Lichen

Fluorinated α-Helical Polypeptides Synchronize Mucus Permeation and Cell Penetration toward Highly Efficient Pulmonary siRNA Delivery against Acute Lung Injury.

Ge, Chenglong; Yang, Jiandong; Duan, Shanzhou; Liu, Yong; Meng, Fenghua; Yin, Lichen.

Afiliação

Ge C; Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.
Yang J; Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.
Duan S; Department of Thoracic Surgery, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.
Liu Y; Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.
Meng F; Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Yin L; Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.

Nano Lett ; 20(3): 1738-1746, 2020 03 11.

Article em En | MEDLINE | ID: mdl-32039603

Assuntos

Lesão Pulmonar Aguda; Macrófagos/metabolismo; Muco/metabolismo; Peptídeos; RNA Interferente Pequeno; Lesão Pulmonar Aguda/tratamento farmacológico; Lesão Pulmonar Aguda/genética; Lesão Pulmonar Aguda/metabolismo; Lesão Pulmonar Aguda/patologia; Animais; Sistemas de Liberação de Medicamentos; Técnicas de Silenciamento de Genes; Halogenação; Macrófagos/patologia; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Peptídeos/química; Peptídeos/farmacologia; Conformação Proteica em alfa-Hélice; Células RAW 264.7; RNA Interferente Pequeno/química; RNA Interferente Pequeno/genética; RNA Interferente Pequeno/farmacologia

Palavras-chave

Anti-inflammation therapy; cell penetration; fluorination; helical polypeptide; mucus permeation; pulmonary siRNA delivery

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / RNA Interferente Pequeno / Lesão Pulmonar Aguda / Macrófagos / Muco Limite: Animals Idioma: En Revista: Nano Lett Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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