Arsenic and benzo[a]pyrene co-exposure acts synergistically in inducing cancer stem cell-like property and tumorigenesis by epigenetically down-regulating SOCS3 expression.

Wang, Zhishan; Yang, Ping; Xie, Jie; Lin, Hsuan-Pei; Kumagai, Kazuyoshi; Harkema, Jack; Yang, Chengfeng

Wang, Zhishan; Yang, Ping; Xie, Jie; Lin, Hsuan-Pei; Kumagai, Kazuyoshi; Harkema, Jack; Yang, Chengfeng.

Afiliação

Wang Z; Department of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, KY, USA. Electronic address: Zhishan.wang@uky.edu.
Yang P; Department of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, KY, USA; School of Public Health, Guangzhou Medical University, Guangzhou, Guangdong, PR China.
Xie J; Department of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, KY, USA; School of Health Sciences, Wuhan University, Wuhan, Hubei, PR China.
Lin HP; Department of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, KY, USA.
Kumagai K; Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
Harkema J; Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
Yang C; Department of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, KY, USA.

Environ Int ; 137: 105560, 2020 04.

Article em En | MEDLINE | ID: mdl-32062438

Assuntos

Arsênio; Benzo(a)pireno; Carcinogênese; Carcinógenos Ambientais; Epigênese Genética; Proteína 3 Supressora da Sinalização de Citocinas; Animais; Arsênio/toxicidade; Benzo(a)pireno/toxicidade; Carcinogênese/induzido quimicamente; Carcinógenos Ambientais/toxicidade; Transformação Celular Neoplásica; Regulação para Baixo; Feminino; Humanos; Masculino; Camundongos; Células-Tronco Neoplásicas; Proteína 3 Supressora da Sinalização de Citocinas/metabolismo

Palavras-chave

Arsenic and benzo[a]pyrene co-exposure; Aryl hydrocarbon receptor (AhR); Cancer stem cell (CSC)-like property; Mixture exposure; Suppressor of Variegation 39 Homolog 1 (SUV39H1); Suppressor of cytokine signaling 3 (SOCS3); Tumorigenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arsênio / Benzo(a)pireno / Carcinógenos Ambientais / Epigênese Genética / Carcinogênese / Proteína 3 Supressora da Sinalização de Citocinas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Environ Int Ano de publicação: 2020 Tipo de documento: Article

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