Constitutive CHK1 Expression Drives a pSTAT3-CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth.

Khanna, Anchit; Thoms, Julie A I; Stringer, Brett W; Chung, Sylvia A; Ensbey, Kathleen S; Jue, Toni Rose; Jahan, Zeenat; Subramanian, Shruthi; Anande, Govardhan; Shen, Han; Unnikrishnan, Ashwin; McDonald, Kerrie L; Day, Bryan W; Pimanda, John E

Khanna, Anchit; Thoms, Julie A I; Stringer, Brett W; Chung, Sylvia A; Ensbey, Kathleen S; Jue, Toni Rose; Jahan, Zeenat; Subramanian, Shruthi; Anande, Govardhan; Shen, Han; Unnikrishnan, Ashwin; McDonald, Kerrie L; Day, Bryan W; Pimanda, John E.

Afiliação

Khanna A; Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia. jpimanda@unsw.edu.au a.khanna@unsw.edu.au.
Thoms JAI; Prince of Wales Clinical School, University of New South Wales Sydney, New South Wales, Australia.
Stringer BW; Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
Chung SA; School of Medical Sciences, University of New South Wales Sydney, New South Wales, Australia.
Ensbey KS; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Jue TR; Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
Jahan Z; Prince of Wales Clinical School, University of New South Wales Sydney, New South Wales, Australia.
Subramanian S; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Anande G; Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
Shen H; Prince of Wales Clinical School, University of New South Wales Sydney, New South Wales, Australia.
Unnikrishnan A; Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
McDonald KL; Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.
Day BW; Prince of Wales Clinical School, University of New South Wales Sydney, New South Wales, Australia.
Pimanda JE; Adult Cancer Program, Lowy Cancer Research Centre, University of New South Wales Sydney, New South Wales, Australia.

Mol Cancer Res ; 18(5): 709-722, 2020 05.

Article em En | MEDLINE | ID: mdl-32079743

Assuntos

Autoantígenos/metabolismo; Biomarcadores Tumorais/metabolismo; Quinase 1 do Ponto de Checagem/metabolismo; Regulação Neoplásica da Expressão Gênica; Glioblastoma/patologia; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Proteínas de Membrana/metabolismo; Fator de Transcrição STAT3/metabolismo; Animais; Apoptose; Autoantígenos/genética; Biomarcadores Tumorais/genética; Movimento Celular; Proliferação de Células; Quinase 1 do Ponto de Checagem/genética; Feminino; Glioblastoma/genética; Glioblastoma/metabolismo; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/genética; Proteínas de Membrana/genética; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos NOD; Camundongos Nus; Camundongos SCID; Fosforilação; Prognóstico; Fator de Transcrição STAT3/genética; Taxa de Sobrevida; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoantígenos / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Glioblastoma / Peptídeos e Proteínas de Sinalização Intracelular / Fator de Transcrição STAT3 / Quinase 1 do Ponto de Checagem / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Mol Cancer Res Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article

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