Oral food challenges: Special considerations.

OBJECTIVE: To reinforce special considerations when offering and conducting oral food challenges (OFCs). DATA SOURCES: Published studies and reviews. STUDY SELECTIONS: Studies concerning OFCs and their conduct. RESULTS: Multiple OFC protocols for various clinical situations and foods were reviewed. CONCLUSION: OFCs are used for the definitive diagnosis of food allergy. Risk and benefit assessment guide the OFC procedure. The conduct of OFCs is influenced by multiple factors, including age, food, and goal of the challenge.