Critical role of PD-L1 expression on non-tumor cells rather than on tumor cells for effective anti-PD-L1 immunotherapy in a transplantable mouse hematopoietic tumor model.

Rodriguez-Barbosa, Jose-Ignacio; Azuma, Miyuki; Zelinskyy, Gennadiy; Perez-Simon, Jose-Antonio; Del Rio, Maria-Luisa

Rodriguez-Barbosa, Jose-Ignacio; Azuma, Miyuki; Zelinskyy, Gennadiy; Perez-Simon, Jose-Antonio; Del Rio, Maria-Luisa.

Afiliação

Rodriguez-Barbosa JI; Transplantation Immunobiology Section, Institute of Molecular Biology, Proteomics and Genomics, University of Leon, Campus de Vegazana s/n, 24071, León, Spain. ignacio.barbosa@unileon.es.
Azuma M; Department of Molecular Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan.
Zelinskyy G; Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, 45147, Germany.
Perez-Simon JA; Department of Hematology, University Hospital Virgen del Rocio/Institute of Biomedicine (IBIS/CSIC/CIBERONC), Seville, 41013, Spain.
Del Rio ML; Transplantation Immunobiology Section, Institute of Molecular Biology, Proteomics and Genomics, University of Leon, Campus de Vegazana s/n, 24071, León, Spain. m.delrio@unileon.es.

Cancer Immunol Immunother ; 69(6): 1001-1014, 2020 Jun.

Article em En | MEDLINE | ID: mdl-32088772

Assuntos

Anticorpos Monoclonais/uso terapêutico; Imunoterapia/métodos; Receptor de Morte Celular Programada 1/metabolismo; Animais; Anticorpos Monoclonais/farmacologia; Modelos Animais de Doenças; Humanos; Camundongos; Transfecção

Palavras-chave

CRISPR/Cas9; Hematological malignancies; Immune checkpoint blockade; PD-1 (programmed death-1); PD-L1 (programmed death-ligand 1)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor de Morte Celular Programada 1 / Imunoterapia / Anticorpos Monoclonais Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Immunol Immunother Assunto da revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha

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