Heterogeneous components of lung adenocarcinomas confer distinct EGFR mutation and PD-L1 expression.

Cai, Yiran; Wu, Hongbo; Shi, Xiaoqin; Dong, Yujie; Chang, Xiujun; Zhang, Li; Zhou, Lijuan; Su, Dan; Yang, Ming

Cai, Yiran; Wu, Hongbo; Shi, Xiaoqin; Dong, Yujie; Chang, Xiujun; Zhang, Li; Zhou, Lijuan; Su, Dan; Yang, Ming.

Afiliação

Cai Y; Department of Pathology, Beijing Chest Hospital, Capital Medical University, 97 Beiguan Machang Rd. Tongzhou District, Beijing, 101147, China. cyr_71@163.com.
Wu H; Department of Pathology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 100 Haining Rd, Hongkou District, Shanghai, 200080, China. cyr_71@163.com.
Shi X; Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, 97 Beiguan Machang Rd. Tongzhou District, Beijing, 101147, China.
Dong Y; Department of Pathology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 100 Haining Rd, Hongkou District, Shanghai, 200080, China.
Chang X; Department of Pathology, Beijing Chest Hospital, Capital Medical University, 97 Beiguan Machang Rd. Tongzhou District, Beijing, 101147, China.
Zhang L; Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, 97 Beiguan Machang Rd. Tongzhou District, Beijing, 101147, China.
Zhou L; Department of Pathology, Beijing Chest Hospital, Capital Medical University, 97 Beiguan Machang Rd. Tongzhou District, Beijing, 101147, China.
Su D; Department of Pathology, Beijing Chest Hospital, Capital Medical University, 97 Beiguan Machang Rd. Tongzhou District, Beijing, 101147, China.
Yang M; Department of Pathology, Beijing Chest Hospital, Capital Medical University, 97 Beiguan Machang Rd. Tongzhou District, Beijing, 101147, China.

BMC Cancer ; 20(1): 148, 2020 Feb 24.

Article em En | MEDLINE | ID: mdl-32093629

Assuntos

Adenocarcinoma de Pulmão/genética; Antígeno B7-H1/biossíntese; Neoplasias Pulmonares/genética; Mutação; Adenocarcinoma de Pulmão/tratamento farmacológico; Adenocarcinoma de Pulmão/metabolismo; Adenocarcinoma de Pulmão/patologia; Adulto; Idoso; Idoso de 80 Anos ou mais; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Antígeno B7-H1/antagonistas & inibidores; Antígeno B7-H1/genética; Antígeno B7-H1/metabolismo; Receptores ErbB/antagonistas & inibidores; Receptores ErbB/genética; Feminino; Heterogeneidade Genética; Humanos; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patologia; Masculino; Pessoa de Meia-Idade; Gradação de Tumores; Estadiamento de Neoplasias; Inibidores de Proteínas Quinases/uso terapêutico; Taxa de Sobrevida; Adulto Jovem

Palavras-chave

EGFR mutation; Heterogeneity; Lung adenocarcinoma; PD-L1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antígeno B7-H1 / Adenocarcinoma de Pulmão / Neoplasias Pulmonares / Mutação Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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