Reversal of synaptic and behavioral deficits in a 16p11.2 duplication mouse model via restoration of the GABA synapse regulator Npas4.

Rein, Benjamin; Tan, Tao; Yang, Fengwei; Wang, Wei; Williams, Jamal; Zhang, Freddy; Mills, Alea; Yan, Zhen

Rein, Benjamin; Tan, Tao; Yang, Fengwei; Wang, Wei; Williams, Jamal; Zhang, Freddy; Mills, Alea; Yan, Zhen.

Afiliação

Rein B; Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.
Tan T; Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.
Yang F; Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.
Wang W; Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.
Williams J; Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.
Zhang F; Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.
Mills A; Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY, 11724, USA.
Yan Z; Department of Physiology and Biophysics, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA. zhenyan@buffalo.edu.

Mol Psychiatry ; 26(6): 1967-1979, 2021 06.

Article em En | MEDLINE | ID: mdl-32099100

Assuntos

Transtorno do Espectro Autista; Deleção Cromossômica; Animais; Transtorno do Espectro Autista/genética; Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética; Cromossomos Humanos Par 16/genética; Variações do Número de Cópias de DNA/genética; Humanos; Camundongos; Sinapses; Ácido gama-Aminobutírico

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Deleção Cromossômica / Transtorno do Espectro Autista Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Psychiatry Assunto da revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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