Affinity Maturation of Macrocyclic Peptide Modulators of Lys48-Linked Diubiquitin by a Twofold Strategy.

Huang, Yichao; Nawatha, Mickal; Livneh, Ido; Rogers, Joseph M; Sun, Hao; Singh, Sumeet K; Ciechanover, Aaron; Brik, Ashraf; Suga, Hiroaki

Huang, Yichao; Nawatha, Mickal; Livneh, Ido; Rogers, Joseph M; Sun, Hao; Singh, Sumeet K; Ciechanover, Aaron; Brik, Ashraf; Suga, Hiroaki.

Afiliação

Huang Y; Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-0033, Japan.
Nawatha M; Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa, 3200008, Israel.
Livneh I; The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, 3200008, Israel.
Rogers JM; Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-0033, Japan.
Sun H; Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa, 3200008, Israel.
Singh SK; Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa, 3200008, Israel.
Ciechanover A; The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, 3200008, Israel.
Brik A; Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa, 3200008, Israel.
Suga H; Department of Chemistry, School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-0033, Japan.

Chemistry ; 26(36): 8022-8027, 2020 Jun 26.

Article em En | MEDLINE | ID: mdl-32105365

Assuntos

Aminoácidos/química; Peptídeos/química; Complexo de Endopeptidases do Proteassoma/química; Humanos; Biblioteca de Peptídeos; Complexo de Endopeptidases do Proteassoma/genética; Complexo de Endopeptidases do Proteassoma/metabolismo; Alinhamento de Sequência; Ubiquitinas/genética

Palavras-chave

RaPID system; diubiquitin; macrocyclic peptides; messenger RNA display; proteasome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Complexo de Endopeptidases do Proteassoma / Aminoácidos Limite: Humans Idioma: En Revista: Chemistry Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

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