Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy.

Misra, Chaitali; Bangru, Sushant; Lin, Feikai; Lam, Kin; Koenig, Sara N; Lubbers, Ellen R; Hedhli, Jamila; Murphy, Nathaniel P; Parker, Darren J; Dobrucki, Lawrence W; Cooper, Thomas A; Tajkhorshid, Emad; Mohler, Peter J; Kalsotra, Auinash

Misra, Chaitali; Bangru, Sushant; Lin, Feikai; Lam, Kin; Koenig, Sara N; Lubbers, Ellen R; Hedhli, Jamila; Murphy, Nathaniel P; Parker, Darren J; Dobrucki, Lawrence W; Cooper, Thomas A; Tajkhorshid, Emad; Mohler, Peter J; Kalsotra, Auinash.

Afiliação

Misra C; Department of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
Bangru S; Department of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Cancer Center at Illinois, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
Lin F; Department of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
Lam K; Department of Physics, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Centers for Macromolecular Modeling, Bioinformatics and Experimental Molecular Imaging at Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
Koenig SN; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Lubbers ER; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Hedhli J; Department of Bioengineering, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Centers for Macromolecular Modeling, Bioinformatics and Experimental Molecular Imaging at Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
Murphy NP; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Parker DJ; Department of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
Dobrucki LW; Department of Bioengineering, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Centers for Macromolecular Modeling, Bioinformatics and Experimental Molecular Imaging at Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Cancer
Cooper TA; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Tajkhorshid E; Department of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Department of Physics, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Department of Bioengineering, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Centers for Macromolecular Modeling, Bioin
Mohler PJ; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Kalsotra A; Department of Biochemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Cancer Center at Illinois, University of Illinois, Urbana-Champaign, Urbana, IL, USA. Electronic address: kal

Dev Cell ; 52(6): 748-763.e6, 2020 03 23.

Article em En | MEDLINE | ID: mdl-32109384

Assuntos

Potenciais de Ação; Frequência Cardíaca; Distrofia Miotônica/genética; Fatores de Processamento de RNA/genética; Splicing de RNA; Proteínas Repressoras/genética; Adulto; Animais; Células Cultivadas; Feminino; Humanos; Masculino; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos ICR; MicroRNAs/genética; MicroRNAs/metabolismo; Pessoa de Meia-Idade; Miócitos Cardíacos/metabolismo; Miócitos Cardíacos/fisiologia; Distrofia Miotônica/metabolismo; Distrofia Miotônica/fisiopatologia; Canais de Potássio de Abertura Dependente da Tensão da Membrana/genética; Canais de Potássio de Abertura Dependente da Tensão da Membrana/metabolismo; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Fatores de Processamento de RNA/metabolismo; Proteínas Repressoras/metabolismo; Canais de Sódio Disparados por Voltagem/genética; Canais de Sódio Disparados por Voltagem/metabolismo

Palavras-chave

alternative splicing; cardiac arrhythmias; genome editing; genomics; ion channels; microRNA; molecular dynamics; myotonic dystrophy; protein-RNA interactions

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Potenciais de Ação / Splicing de RNA / Fatores de Processamento de RNA / Frequência Cardíaca / Distrofia Miotônica Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Dev Cell Assunto da revista: EMBRIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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