Physically-plausible modelling of biomolecular systems: A simplified, energy-based model of the mitochondrial electron transport chain.
J Theor Biol
; 493: 110223, 2020 05 21.
Article
em En
| MEDLINE
| ID: mdl-32119969
ABSTRACT
Advances in systems biology and whole-cell modelling demand increasingly comprehensive mathematical models of cellular biochemistry. Such models require the development of simplified representations of specific processes which capture essential biophysical features but without unnecessarily complexity. Recently there has been renewed interest in thermodynamically-based modelling of cellular processes. Here we present an approach to developing of simplified yet thermodynamically consistent (hence physically plausible) models which can readily be incorporated into large scale biochemical descriptions but which do not require full mechanistic detail of the underlying processes. We illustrate the approach through development of a simplified, physically plausible model of the mitochondrial electron transport chain and show that the simplified model behaves like the full system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biologia de Sistemas
/
Modelos Biológicos
Idioma:
En
Revista:
J Theor Biol
Ano de publicação:
2020
Tipo de documento:
Article