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IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.
Ansotegui, Ignacio J; Melioli, Giovanni; Canonica, Giorgio Walter; Caraballo, Luis; Villa, Elisa; Ebisawa, Motohiro; Passalacqua, Giovanni; Savi, Eleonora; Ebo, Didier; Gómez, R Maximiliano; Luengo Sánchez, Olga; Oppenheimer, John J; Jensen-Jarolim, Erika; Fischer, David A; Haahtela, Tari; Antila, Martti; Bousquet, Jean J; Cardona, Victoria; Chiang, Wen Chin; Demoly, Pascal M; DuBuske, Lawrence M; Ferrer Puga, Marta; Gerth van Wijk, Roy; González Díaz, Sandra Nora; Gonzalez-Estrada, Alexei; Jares, Edgardo; Kalpaklioglu, Ayse Füsun; Kase Tanno, Luciana; Kowalski, Marek L; Ledford, Dennis K; Monge Ortega, Olga Patricia; Morais Almeida, Mário; Pfaar, Oliver; Poulsen, Lars K; Pawankar, Ruby; Renz, Harald E; Romano, Antonino G; Rosário Filho, Nelson A; Rosenwasser, Lanny; Sánchez Borges, Mario A; Scala, Enrico; Senna, Gian-Enrico; Sisul, Juan Carlos; Tang, Mimi L K; Thong, Bernard Yu-Hor; Valenta, Rudolf; Wood, Robert A; Zuberbier, Torsten.
Afiliação
  • Ansotegui IJ; Hospital Quironsalud Bizkaia, Bilbao-Erandio, Spain.
  • Melioli G; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
  • Canonica GW; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Personalized Medicine, Asthma and Allergy, Humanitas Research Hospital, Rozzano, Milan, Italy.
  • Caraballo L; Institute for Immunological Research, University of Cartagena, Cartagena, Colombia.
  • Villa E; Azienda Sanitaria Locale di Vercelli, S.C. Pneumologia, Vercelli, Italia.
  • Ebisawa M; Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan.
  • Passalacqua G; Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, Genoa, Italy.
  • Savi E; Ospedale Civile, Gossolengo, PC, Italy.
  • Ebo D; Department of Immunology - Allergology - Rheumatology, Antwerp University Hospital, Antwerp University, Department Immunology and Allergology, AZ Jan Palfijn Gent, Ghent, Belgium.
  • Gómez RM; Universidad Católica de Salta, Fundación Ayre, Buenos Aires, Argentina.
  • Luengo Sánchez O; Allergy Section, Department of Internal Medicine, Vall d'Hebron University Hospital, Barcelona, Spain.
  • Oppenheimer JJ; Pulmonary & Allergy Associates, Denville, NJ, USA.
  • Jensen-Jarolim E; Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, The Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, Vienna, Austria.
  • Fischer DA; Fischer Medicine Professional Corporation, Barrie, Ontario, Canada.
  • Haahtela T; Skin and Allergy Hospital, University of Helsinki, Helsinki, Finland.
  • Antila M; Clínica de Alergía, Sorocaba, São Paulo, Brazil.
  • Bousquet JJ; MACVIA-France, Montpellier, France.
  • Cardona V; INSERM, Villejuif, France.
  • Chiang WC; Université Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, France.
  • Demoly PM; Euforea, Brussels, Belgium.
  • DuBuske LM; CHU Montpellier, France.
  • Ferrer Puga M; Universitat Autónoma de Barcelona, Hospital Universitario Vall d'Hebron, Servicio de Medicina Interna, Sección de Alergología, Barcelona, Spain.
  • Gerth van Wijk R; Mount Elizabeth Medical Centre, Chiang Children's Allergy & Asthma Clinic, Singapore, Singapore.
  • González Díaz SN; University Hospital Montpellier, Montpellier, France.
  • Gonzalez-Estrada A; Sorbonne Université, Paris, France.
  • Jares E; Immunology Research Institute of New England, Gardner, MA, USA.
  • Kalpaklioglu AF; The Unidad de Educación Médica, Department of Medical Education, School of Medicine, Clinica Universitad de Navarra, Navarra, Spain.
  • Kase Tanno L; Erasmus MC, Sector Allergologie, Rotterdam, the Netherlands.
  • Kowalski ML; Universidad Autónoma de Nuevo León, Hospital Universitario, Monterrey, Nuevo León, Mexico.
  • Ledford DK; Department of Allergy, Mayo Clinic, Jacksonville, FL, USA.
  • Monge Ortega OP; Femeca Femedica, Buenos Aires, Argentina.
  • Morais Almeida M; Kirikkale Universitesi, Tip Fakultesi, Kirikkale, Turkey.
  • Pfaar O; Hospital Sírio Libanês, University of São Paulo, São Paulo, Brazil.
  • Poulsen LK; Faculty of Medicine, Department of Clinical Immunology & Allergy, Medical University of Lódz, Lódz, Poland.
  • Pawankar R; University of South Florida College of Medicine, Tampa, FL, USA.
  • Renz HE; Allergology Unit, San Juan de Dios Hospital, University of Costa Rica, San José, Costa Rica.
  • Romano AG; Hospital CUF-Descobertas, Lisbon, Portugal.
  • Rosário Filho NA; Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
  • Rosenwasser L; Gentofte University Hospital, Lab for Allergology, Allergy Clinic, Hellerup, Denmark.
  • Sánchez Borges MA; Nippon Medical School, Dept. of Otolaryngology, Tokyo, Japan.
  • Scala E; University Hospital GI & MR GmbH, Institute of Laboratory Medicine & Pathology, Standort Marburg, Marburg, Germany.
  • Senna GE; Stallergenes, Rome, Italy.
  • Sisul JC; University of Parana, Curitiba, PR, Brazil.
  • Tang MLK; University of Missouri at Kansas City, School of Medicine, Kansas City, MO, USA.
  • Thong BY; Centro Médico Docente La Trinidad, Caracas, Venezuela.
  • Valenta R; Experimental Allergy Unit, Istituto Dermopatico dell'Immacolata, Rome, Italy.
  • Wood RA; Ospedale Civile Maggiore, Verona, Italy.
  • Zuberbier T; Allergy & Asthma Institute, Asunción, Paraguay.
World Allergy Organ J ; 13(2): 100080, 2020 Feb.
Article em En | MEDLINE | ID: mdl-32128023
Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.
Palavras-chave
AAAAI, American Academy of Allergy Asthma and Immunology; ABA, Allergen Bead Array; ACAAI, American College of Allergy Asthma and Immunology; AEC, Allergen Exposure Chambers; AIT, allergen immunotherapy; AP, Alkaline Phosphatase; AU/mL, Allergenic Units milliLiter; Allergy; Anti-IgE, Antibody against IgE; BAT, Basophil Activation Test; BAU/mL, Biologic Allergenic Units milliLiter; CBA, Cytometric Bead Array; CCD, Cross-reactive Carbohydrate Determinants; CDER, Center for Drug Evaluation and Research (USA); CL, Chemiluminescence; CaFE, Calibrated Fluorescence Enhancement; DBPCFC, Double-Blind Placebo-Controlled Food Challenge; Diagnostic strategies; EAACI, European Academy of Allergy and Immunology; EIA, Enzyme Immune Assay; ELISA, Enzyme Linked Immuno Sorbent Analysis; EMEA, European MEdicine Agencies; ENPP-3, EctoNucleotide Pyrophosphatase/Phosphodiesterase 3; FACS, Fluorescence-Activated Cell Sorting; FDA, Food and Drug Administration (U.S. Department of Health and Human Services); FEIA, Fluorescent Enzyme Immunoassays; FcεRI, High affinity IgE receptor; H1, Histamine 1 receptor; H2, Histamine 2 receptor; HPO, Horseradish Peroxidase; IDT, Intradermal Test; ISAC, Immuno-Solid phase Allergen Chip; IUIS, International Union of Immunological Societies; IVD, in vitro diagnostic tool; IgE; IgE, immunoglobulin E; In vitro tests; LAMP-3, Lysosomal-Associated Membrane Protein; MBAD, Molecule Based Allergy Diagnostics; MRGPRX2, Mas-related G protein receptor 2; NIH, National Institutes of Health (USA); NMBAs, NeuroMuscular Blocking Agents; NPA, Negative Percent Agreement; NSAIDs, Non-Steroidal Anti-Inflammatory Drugs; PPA, Positive Percent Agreement; PPT, Prick-Prick Test; RAST, Radio Allergo Sorbent Test; SCAR, severe cutaneous adverse drug reactions; SPT, Skin prick test; Skin tests; kUA/L, kilo Units of Allergen/Liter for allergen-specific IgE antibody assays; mAb, Monoclonal Antibody; pNPP, p-Nitrophenylphosphate; sIgE, specific IgE; w/v, weight /volume
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Diagnostic_studies Idioma: En Revista: World Allergy Organ J Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Diagnostic_studies Idioma: En Revista: World Allergy Organ J Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha