The effects of circuit resistance training on plasma progranulin level, insulin resistance and body composition in obese men.
Horm Mol Biol Clin Investig
; 41(2)2020 Mar 09.
Article
em En
| MEDLINE
| ID: mdl-32146440
ABSTRACT
Background Progranulin (PGRN) is implicated in obesity and insulin resistance (IR). The aim of this study was to evaluate the effects of 8 weeks of circuit resistance training (CRT) on plasma PGRN, IR and body composition in obese men. Materials and methods Twenty-eight healthy obese men [age 36 ± 7.7 years, body weight (BW) 96.4 ± 15.6 kg, body mass index (BMI) 32.4 ± 4.5 kg/m2] completed the study. Subjects were randomly assigned to two groups of control and training. Subjects in the training group underwent training for 8 weeks, 3 times a week. Blood samples and anthropometric characteristics were taken before the commencement of the exercise protocol and 72 h after the last training session. The homeostatic model assessment of insulin resistance (HOMA-IR) was used to measure IR. Results BW, BF%, BMI, waist-hip ratio (WHR), HOMA-IR and plasma PGRN levels except lean body mass (LBM) were significantly reduced in the training group (p < 0.05). Additionally, except for LBM, subjects in the training group had significantly decreased BW, BF%, BMI, WHR, HOMA-IR and plasma PGRN levels compared to changes in those in the control group (p < 0.05). Significant correlations were found between the changes in plasma PGRN and the changes in insulin, HOMA-IR and BMI (p < 0.05). Conclusions The findings showed that 8 weeks of CRT improved body composition and IR which were accompanied by reduced plasma PGRN levels. This study suggests that CRT has the potential for obese individuals to counteract obesity-associated health impairments.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Composição Corporal
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Resistência à Insulina
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Treinamento Resistido
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Progranulinas
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Obesidade
Tipo de estudo:
Clinical_trials
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Prognostic_studies
Limite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Horm Mol Biol Clin Investig
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Irã