Overview and Current Status of Peptide Receptor Radionuclide Therapy.
Surg Oncol Clin N Am
; 29(2): 317-326, 2020 Apr.
Article
em En
| MEDLINE
| ID: mdl-32151363
ABSTRACT
Peptide receptor radionuclide therapy (PRRT) is an effective form of treatment of patients with metastatic neuroendocrine tumors, delivering modest objective tumor response rates but notable survival and symptomatic benefits. The first PRRT approved by the US Food and Drug Administration was lutetium 177-DOTATATE and is for use in adults with somatostatin receptor-positive gastroenteropancreatic neuroendocrine tumors. The treatment paradigm typically leads to significant improvement in symptomology coupled with an extended period of progression-free survival. Side effects are limited, with a small fraction of individuals experiencing clinically significant long-term renal or hematologic toxicity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Radioisótopos
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Neoplasias Gástricas
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Receptores de Somatostatina
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Tumores Neuroendócrinos
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Compostos Radiofarmacêuticos
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Neoplasias Intestinais
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Lutécio
Limite:
Animals
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Humans
Idioma:
En
Revista:
Surg Oncol Clin N Am
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2020
Tipo de documento:
Article