ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface.

Yang, Jinling; LeBlanc, Michelle E; Cano, Issahy; Saez-Torres, Kahira L; Saint-Geniez, Magali; Ng, Yin-Shan; D'Amore, Patricia A

Yang, Jinling; LeBlanc, Michelle E; Cano, Issahy; Saez-Torres, Kahira L; Saint-Geniez, Magali; Ng, Yin-Shan; D'Amore, Patricia A.

Afiliação

Yang J; Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts 02115.
LeBlanc ME; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02115.
Cano I; Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts 02115.
Saez-Torres KL; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02115.
Saint-Geniez M; Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts 02115.
Ng YS; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02115.
D'Amore PA; Schepens Eye Research Institute of Massachusetts Eye and Ear, Boston, Massachusetts 02115.

J Biol Chem ; 295(19): 6641-6651, 2020 05 08.

Article em En | MEDLINE | ID: mdl-32193206

Assuntos

Proteína ADAM10/metabolismo; Proteína ADAM17/metabolismo; Secretases da Proteína Precursora do Amiloide/metabolismo; Células Endoteliais da Veia Umbilical Humana/metabolismo; Proteínas de Membrana/metabolismo; Sialoglicoproteínas/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Células Endoteliais da Veia Umbilical Humana/patologia; Humanos; Inflamação/metabolismo; Inflamação/patologia

Palavras-chave

endomucin; endothelial cell; endothelium; glycocalyx; glycoprotein; inflammation; leukocyte; matrix metalloproteinase (MMP); proteolytic enzyme

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sialoglicoproteínas / Fator de Necrose Tumoral alfa / Secretases da Proteína Precursora do Amiloide / Células Endoteliais da Veia Umbilical Humana / Proteína ADAM10 / Proteína ADAM17 / Proteínas de Membrana Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article

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