TRK inhibition in soft tissue sarcomas: A comprehensive review.
Semin Oncol
; 47(1): 73-84, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-32201016
ABSTRACT
Soft-tissue sarcomas (STS) are a group of rare mesenchymal tumors that constitutes â¼1% of all solid tumors. It remains a rare tumor which lacks effective treatment options. Precision oncology may be of interest in this regard by identifying potential targets for emerging novel therapies. Neurotrophic receptor tyrosine kinase (NTRK) fusions are rare oncogenic driver mutations found in a broad range of common and rare tumor subtypes including STS. The recent approvals of NTRK inhibitors (larotrectinib and entrectinib) represent new therapeutic options in the drug armamentarium especially valuable in advanced STS given the paucity of treatment options and the generally poor prognosis of these tumors. We review the methods used to detect NTRK fusions in STS with focus on incidence, diagnosis and management of these rare and intriguing oncogenic targets.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoma
/
Biomarcadores Tumorais
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Receptores Proteína Tirosina Quinases
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Inibidores de Proteínas Quinases
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Semin Oncol
Ano de publicação:
2020
Tipo de documento:
Article