Effect of the topical Klox fluorescence biomodulation system on the healing of canine surgical wounds.
Vet Surg
; 49(4): 719-727, 2020 May.
Article
em En
| MEDLINE
| ID: mdl-32212345
ABSTRACT
OBJECTIVE:
To determine the effect of the Klox fluorescence biomodulation system (Phovia) on the healing of surgical wounds. STUDYDESIGN:
Prospective, blinded, controlled clinical trial. SAMPLE POPULATION Healthy dogs undergoing orthopedic surgery (n = 10).METHODS:
Half of the length of each surgical wound was treated with Phovia, and the remaining 50% was treated with saline solution on the first day after surgery and every 3 days until day 13. Wound healing of treated and control areas within each wound was evaluated via macroscopic assessment and histological and immunohistochemical analysis of treated and control wounds.RESULTS:
The areas treated with Phovia achieved lower histology scores (P = .001), consistent with complete re-epithelialization, less inflammation of the dermal layer, and greater and more regular deposition of collagen. According to immunohistochemistry, expression of factor VIII, epidural growth factor, decorin, collagen III, and Ki67 was increased in treated compared with untreated tissues.CONCLUSION:
Phovia therapy improved re-epithelialization, decreased dermal inflammation, and improved matrix formation in uncomplicated cutaneous incisional wounds by regulating the expression of key biological mediators. CLINICALSIGNIFICANCE:
Phovia may be a beneficial adjunct to promote the healing of incisional wounds.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Cicatrização
/
Ferida Cirúrgica
/
Fatores Imunológicos
Tipo de estudo:
Observational_studies
Limite:
Animals
Idioma:
En
Revista:
Vet Surg
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Itália