Pirfenidone Inhibits Cell Proliferation and Collagen I Production of Primary Human Intestinal Fibroblasts.

Cui, Yingying; Zhang, Mengfan; Leng, Changsen; Blokzijl, Tjasso; Jansen, Bernadien H; Dijkstra, Gerard; Faber, Klaas Nico

Cui, Yingying; Zhang, Mengfan; Leng, Changsen; Blokzijl, Tjasso; Jansen, Bernadien H; Dijkstra, Gerard; Faber, Klaas Nico.

Afiliação

Cui Y; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Zhang M; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Leng C; Department of Biomedical Sciences of Cells and Systems, section Molecular Cell Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Blokzijl T; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Jansen BH; Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Dijkstra G; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Faber KN; Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.

Cells ; 9(3)2020 03 22.

Article em En | MEDLINE | ID: mdl-32235767

Assuntos

Colágeno Tipo I/biossíntese; Fibroblastos/citologia; Fibroblastos/metabolismo; Intestinos/citologia; Piridonas/farmacologia; Morte Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Proteínas da Matriz Extracelular/metabolismo; Fibroblastos/efeitos dos fármacos; Humanos; Fosforilação/efeitos dos fármacos; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Proteínas Quinases S6 Ribossômicas 70-kDa/metabolismo; Transdução de Sinais/efeitos dos fármacos; Serina-Treonina Quinases TOR/metabolismo; Fator de Crescimento Transformador beta1/farmacologia

Palavras-chave

TGF-ß1; collagen; fibroblast; inflammatory bowel disease; intestinal fibrosis; mTOR; pirfenidone

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Colágeno Tipo I / Fibroblastos / Intestinos Limite: Humans Idioma: En Revista: Cells Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

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