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Cysteine depletion induces pancreatic tumor ferroptosis in mice.
Badgley, Michael A; Kremer, Daniel M; Maurer, H Carlo; DelGiorno, Kathleen E; Lee, Ho-Joon; Purohit, Vinee; Sagalovskiy, Irina R; Ma, Alice; Kapilian, Jonathan; Firl, Christina E M; Decker, Amanda R; Sastra, Steve A; Palermo, Carmine F; Andrade, Leonardo R; Sajjakulnukit, Peter; Zhang, Li; Tolstyka, Zachary P; Hirschhorn, Tal; Lamb, Candice; Liu, Tong; Gu, Wei; Seeley, E Scott; Stone, Everett; Georgiou, George; Manor, Uri; Iuga, Alina; Wahl, Geoffrey M; Stockwell, Brent R; Lyssiotis, Costas A; Olive, Kenneth P.
Afiliação
  • Badgley MA; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
  • Kremer DM; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
  • Maurer HC; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • DelGiorno KE; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
  • Lee HJ; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
  • Purohit V; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
  • Sagalovskiy IR; Klinikum rechts der Isar, II, Medizinische Klinik, Technische Universität München, 81675, Munich, Germany.
  • Ma A; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Kapilian J; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Firl CEM; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
  • Decker AR; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Sastra SA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
  • Palermo CF; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
  • Andrade LR; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
  • Sajjakulnukit P; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
  • Zhang L; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
  • Tolstyka ZP; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
  • Hirschhorn T; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
  • Lamb C; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
  • Liu T; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
  • Gu W; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
  • Seeley ES; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
  • Stone E; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
  • Georgiou G; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
  • Manor U; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA.
  • Iuga A; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA.
  • Wahl GM; Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
  • Stockwell BR; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Lyssiotis CA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
  • Olive KP; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Science ; 368(6486): 85-89, 2020 04 03.
Article em En | MEDLINE | ID: mdl-32241947
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Cisteína / Ferroptose Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Cisteína / Ferroptose Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos