Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence.
Commun Biol
; 3(1): 157, 2020 04 02.
Article
em En
| MEDLINE
| ID: mdl-32242137
ABSTRACT
Aging induces cellular and molecular changes including modification of stem cell pools. In particular, alterations in aging neural stem cells (NSCs) are linked to age-related cognitive decline which can be modulated by lifestyle. Nutrient-sensing pathways provide a molecular basis for the link between lifestyle and cognitive decline. Adopting a back-translation strategy using stem cell biology to inform epidemiological analyses, here we show associations between cellular readouts of NSC maintenance and expression levels of nutrient-sensing genes following NSC exposure to aging human serum as well as morphological and gene expression alterations following repeated passaging. Epidemiological analyses on the identified genes showed associations between polymorphisms in SIRT1 and ABTB1 and cognitive performance as well as interactions between SIRT1 genotype and physical activity and between GRB10 genotype and adherence to a Mediterranean diet. Our study contributes to the understanding of neural stem cell molecular mechanisms underlying human cognitive aging and hints at lifestyle modifiable factors.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Exercício Físico
/
Senescência Celular
/
Células-Tronco Neurais
/
Envelhecimento Cognitivo
/
Dieta Saudável
/
Envelhecimento Saudável
/
Hipocampo
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Aged80
País/Região como assunto:
Europa
Idioma:
En
Revista:
Commun Biol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido